Drugs screening

ParaDev offers drug screening to detect new anti-schistosomal molecules activities. The first step is a large in vitro screening either on larval or adult stages. The second one is an in vivo test with the appropriate molecules.

Reyser et al. 2021

Reyser, T., To, T.H., Egwu, C., Paloque, L., Nguyen, M., Hamouy, A., Stigliani, J.L., Bijani, C., Augereau, J.M., Joly, J.P., Portela, J., Havot, J., Marque, S.R.A., Boissier, J., Robert, A., Benoit-Vical, F., Audran, G., 2020. Alkoxyamines Designed as Potential Drugs against Plasmodium and Schistosoma Parasites. Molecules.25.

Pradines, V., Portela, J., Boissier, J., Cosledan, F., Meunier, B., Robert, A., 2011. Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni. Antimicrob. Agents Chemother.55, 2403-2405.

Portela, J., Boissier, J., Gourbal, B., Pradines, V., Colliere, V., Cosledan, F., Meunier, B., Robert, A., 2012. Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. PLoS Negl Trop Dis6, e1474.