ParaDev offers drug screening to detect new anti-schistosomal molecules activities.
The first step is a large in vitro screening either on larval or adult stages. The second one is an in vivo test with the appropriate molecules.
References
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Pradines, V., Portela, J., Boissier, J., Cosledan, F., Meunier, B., Robert, A., 2011. Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni. Antimicrob. Agents Chemother.55, 2403-2405.
Portela, J., Boissier, J., Gourbal, B., Pradines, V., Colliere, V., Cosledan, F., Meunier, B., Robert, A., 2012. Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. PLoS Negl Trop Dis6, e1474.