ParaDev offers drug screening to detect new anti-schistosomal molecules activities.
The first step is a large in vitro screening either on larval or adult stages. The second one is an in vivo test with the appropriate molecules.
References
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Reyser, T., To, T.H., Egwu, C., Paloque, L., Nguyen, M., Hamouy, A., Stigliani, J.L., Bijani, C., Augereau, J.M., Joly, J.P.,Portela, J., Havot, J., Marque, S.R.A., Boissier, J., Robert, A., Benoit-Vical, F., Audran, G., 2020. Alkoxyamines Designed as Potential Drugs against Plasmodium and Schistosoma Parasites. Molecules.25.
Pradines, V.,Portela, J., Boissier, J., Cosledan, F., Meunier, B., Robert, A., 2011. Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni. Antimicrob. Agents Chemother.55, 2403-2405.
Portela, J., Boissier, J., Gourbal, B., Pradines, V., Colliere, V., Cosledan, F., Meunier, B., Robert, A., 2012. Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. PLoS Negl Trop Dis6, e1474.